FINDING THE
MISSING PIECE
FOR SIOD
DRUG THERAPY PHASE 2
BE A PART OF HISTORY MAKING IN SIOD
$350,000
$100,000
$200,000
$300,000
$51,554 RAISED
THE DETAILS
In 2022 we fully funded the first phase of drug therapy for SIOD.
We are working on the 2nd phase which will get us one step closer to having a potential drug to help with symptoms of SIOD.
GET INVOLVED
This phase will cost approximately $350,000. Since SIOD has so many unknowns that research is working to identify, this campaign is just one more step to solving the overall puzzle to find a cure.
FUNDRAISE
We can't do this alone. So we've made it SUPER EASY for you to help us fundraise to reach the goal! It's as easy as setting up your own page and getting started. We'll help you along the way!
DONOR ACKNOWLEDGEMENTS
PIONEERS $5,000 DONORS
ONE RIDE CYCLE
TRAIL BLAZERS $1,000 DONORS
HAGGARD FAMILY
MUSCLE SHOALS CAREER ACADEMY
THORNTON IRON & METAL
SERVICE ONE TRANSPORT
SERVICE ONE TRANSPORT
SERVICE ONE TRANSPORT
OTHEL MCCLANAHAN (PAWPAW)
Champy's
Howell Graves Kindergarten
Franklin Homes
April Sayre in honor of Sam
BRAZIL SIOD FAMILY
BRAZIL SIOD FAMILY
DAVID & DIANE HOLLIMON - IN MEMORY OF JOHN HARRISONBrad Ginevan, MD Shoals Primary CareBrad & Sierra GinevanCharles & ROBIN MullaleyCharles & ROBIN MullaleyStorage City
Nana & Papa (Jackie &Amy Brackin
Sweet Odessa Hair
Mid america roofing
Tracy Bourdon Tool Sales LLC Tracy and Monica Bourdon
Smith Law Firm
keene law firm
MUSCLE SHOALS CITY SCHOOLS
MUSCLE SHOALS CITY SCHOOLS
The Sharp Family
THE TEAL DOOR TEAM
the village shoppe
Trey Bailey
Quench Shoals
Josh Jolene and Rylee Rohling at Rohling’s Diesel Repair
Meraki
Total Lancscape, Inc.
Carter McGuyer Design Group
BUILDERS $100 DONORS
CASS THILMAN - ONE RIDE CYCLE
MISTY ELLIS
LYNN GRIGSBY
JASMINE CHAPIN
BETTIE BUCKNER
LORI BETTEN
NANCIE JONES
JOY HAYES
JONNA DEVANEY
MEAGAN PHILLIPS
RONDA HENLEY
SELENA SOUTH
TAMMY ADCOCK
LEESA WILLIS
LINDA TOOTHMAN
DEBORAH PUTMAN
JILL JONER
JACKSON BYRD
MELINDA WALLACE
ERNEST & MARSHA LANKFORD
Sharpe Family
Ruth Holmes
CLARK PULLEY INDUSTRIES
NATALIE YORK - IN HONOR OF ANNISTON PHILLIPS
NATALIE YORK - IN HONOR OF BANKSTON BARTON
AMY DODSON - IN HONOR OF EMMIT DODSON
WHITNEY POSEY
HADLEY & LISA HOWARD
MALLORY GOODE
BELINDA GARNER
KRISTY SPRINGER
MIKE & CAMILLE SMITH
CHRISTINA TURBERVILLE
CHRISTINA TURBERVILLE
CHRISTINA TURBERVILLE
JEANETTE JONES - IN MEMORY OF BARBARA WIGINTON
CHAN COPELAND
PATSY MOORE
Meredith Moore
PAT NEAL
First Presbyterian Church Sheffield
Leroy & Elaine Willis
GET INVOLVED - DONATE
When completed, this puzzle will be 60x48 inches. It takes 350 pieces to complete this phase of drug therapy totalling $350,000.
You can be a part of this history making endeavor by contributing at one of the following levels:
BUILDER
With each $100 donation, you are part of one puzzle piece. Your name will be painted on the back side of the piece along with the other contributors of this piece and you will receive a puzzle piece magnet.
$100
TRAIL BLAZER
You are purchasing 1 complete piece of the puzzle. With this donation, you will have your name or business painted on the backside of this puzzle piece exclusively, along with up to 5 t-shirts.
$1,000
PIONEER
You are purchasing 5 puzzle pieces. With this donation, you will have your name or business painted on the backside of 5 pieces of the puzzle exclusively, along with up to 10 tshirts
$5,000
We can't do this alone. So we want to empower YOU to raise money for Kruzn For A Kure by doing something you love as a fundraiser. Ideas can range from businesses and schools having employees/students wear jeans or have a hat day and donate $1 to your specific fundraising page for your own puzzle piece. Businesses can coordinate a special day with their customers for proceeds to go toward their fundraising page. The possibilities are endless!
Here's how it works. When you register your event, you'll receive a page that you can personalize with photos and information about why you are fundraising for Kruzn For A Kure. We'll provide you with some graphics you can use on social media as well.
It's easy to spread the word to your family and friends by sharing your page on social media and email. Your friends can donate online directly to your event through your page, just like they would in person. You don't have to worry about collecting money, your fundraising page does it for you!
RESOURCES FOR FUNDRAISING
SCHOOLS
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BUSINESSES
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PURCHASE A T-SHIRT
All proceeds from these shirts goes towards Drug Therapy Phase 2!
These would be perfect for your family, your staff, or your children to wear - especially on Rare Disease Day (February 28)
Shirts are comfort color and super soft and comfy!
All shirts are $35
If you donate $1,000 as a Trailblazer, you get up to 5 of these shirts with your donation.
If you donate $5,000 as a Pioneer, you get up to 10 of these shirts with your donation.
THE DETAILS
PHASE 1
FULLY FUNDED 2022
Background: We now have genetically engineered induced pluripotent stem cells (IPSCs) that can be treated to specifically deplete SMARCAL1 protein using a drug. This will model SIOD, in which all cells of body have impaired production of SMARCAL1 due to genetic .
We can now make tissues/organoids from these IPSCs that are affected with disease in SIOD – this includes “Brain on a Chip” that includes brain tissue and blood vessels that provide nutrients to the brain.
Hypothesis: SMARCAL1 is important for the blood vessel cells dealing with many causes of stress, such as increased temperature. Depletion SMARCAL1 of the tissue/organoids will lead to changes in the cells signaling and temporary narrowing of the brain blood vessels. In SIOD, this is likely what results in migraine like headaches and temporary neurologic dysfunction.
Proposal: Modeling of Neurovascular Disease in SIOD Objective: Use the brain-on-a-chip system maintained underphysiologic conditions to study effects of the lack of SMARCAL1 protein on blood vessel cell function in a brain organoid. To gain insight as to how SMARCAL1 protein causes disease, such as migraine headaches with neurologic dysfunction, this will be constructed using blood vessel cells that can be treated with a drug to induce SMARCAL 1 deficiency.
PHASE 2
$350,000 NEEDED TO FUND
Background: Assuming that Phase 1 is successful in identifying abnormalities in cell signaling, gene expression, or biologic function, the next step will be to perform drug screens to determine if treatment with small molecules can partially or fully correct the pathologic features.
Hypothesis: We expect that the phase 1 studies using neurovascular chips will reveal abnormalities with drug-induced SMARCAL1 depletion that are shared with other diseased tissues, e.g., kidney and blood vessel organoids. We predict that treatment with small molecules as part of drug screens will identify several candidates for further preclinical drug development, which will be pursued in phase 3.
Proposal: Small and Large Scale Drug Screens for Neurovascular Disease. Objective: Perform Screens of repurposed small molecule drugs and a large scale small molecule screen to identify drugs that can correct the biologic abnormalities in the neurovascular model of SIOD. Validate any positive hits in each screen using the Brain on a Chip System.
GET INVOLVED - DONATE
BUILDER
With each $100 donation, you are part of one puzzle piece. Your name will be painted on the back side of the piece along with the other contributors of this piece and you will receive a puzzle piece magnet.
$100
TRAIL BLAZER
You are purchasing 1 complete piece of the puzzle. With this donation, you will have your name or business painted on the backside of this puzzle piece exclusively, along with up to 5 t-shirts.
$1,000
PIONEER
You are purchasing 5 puzzle pieces. With this donation, you will have your name or business painted on the backside of 5 pieces of the puzzle exclusively, along with up to 10 tshirts
$5,000